## Solving the EEG and MEG forward problem using the finite element method

## Introduction

The aim of this tutorial is to solve the EEG and MEG forward problems using the Finite Element Method (FEM).

## Background

The EEG/MEG signals measured on the scalp do not directly reflect the location of the activated neurons. To reconstruct the location and the time-course or spectral content of a source in the brain, various source-localization methods are available. You can read more about the different methods in review papers suggested here.

The level of the activity at a source location is estimated from

- the EEG/MEG activity measured on (around) the scalp
- the spatial arrangement of the electrodes/sensors (
**channel positions**), - the geometrical and electrical/magnetic properties of the head (
**head model**) - the location of the source (
**source model**)

Using this information, source estimation comprises two major steps: (1) Estimation of the potential or field distribution for a known source and for a known model of the head is referred to as **forward modeling**. (2) Estimation of the unknown sources corresponding to the measured EEG or MEG is referred to as **inverse modeling**.

The forward solution can be computed when the head model, the channel positions and the source is given. For distributed source models and for scanning approaches (such as beamforming), the source model is discretizing the brain volume into a volumetric or surface grid. When the forward solution is computed, the **lead field matrix** (= channels X source points matrix) is calculated for each grid point taking into account the head model and the channel positions.

A prerequisite of forward modeling is that the geometrical description of all elements (channel positions, head model and source model) is registered in the same coordination system with the same units. There are different “conventions” how to define a coordinate system, but the precise coordinate system is not relevant, as long as all data is expressed in it consistently (i.e. in the same coordinate system). Here read more about how the different head and mri coordinate systems are defined. The MEG sensors by default are defined relative to anatomical landmarks of the head (the fiducial coils), therefore when the anatomical images are also aligned to these landmarks, the MEG sensors do not need to be re-aligned. EEG data is typically not aligned to the head, therefore, the electrodes have to be re-aligned prior to source-reconstruction (see also this faq and this example).

*Figure 1. Major steps in source reconstruction*

## Procedure

As already mentioned, the goal of this session is to solve the EEG and MEG forward problem, more precisely we want to compute EEG and MEG leadfields so that the inverse problem can be solved in the next session (inverse problem). In order to compute leadfields, there are five main steps that have to be followed.

**create the __mesh__**: in this step the MRI is loaded and processed, the segmentation is performed and finally the mesh is generated;**create the __head-model__**: in this step the geometrical (mesh) and electrical (tissue conductivities) features are merged together;**create the source-model**: in this step a grid of source positions in the gray matter is created;**handle the __sensors__**: loading the electrodes and the gradiometers and aligning the electrodes to the scalp surface if needed;**compute the __leadfield__**, i.e., solve the forward problem: this steps consists of two procedures. First, the so-called transfer matrix is computed; second, the leadfield matrix is estimated.

The first step is the same for solving both the EEG and MEG forward problem, the other four have to be executed separately for EEG and MEG. See Figure1.

*Figure1: pipeline for forward computation using FEM, in the orange box there are the steps which differ between EEG and MEG*

In particular, the EEG forward solution is computed via the method so-called *simbio* which relies on the code that you can find here, while the MEG forward solution calls the *duneuro* method, which makes use of the code developed in the University of Münster, visit this for further details.

The integration of SimBio with FieldTrip is described in the reference below. Please cite this reference if you use the FieldTrip-SimBio pipeline in your research.

Vorwerk, J., Oostenveld, R., Piastra, M.C., Magyari, L., & Wolters, C. H. **The FieldTrip‐SimBio pipeline for EEG forward solutions.** BioMed Eng OnLine (2018) 17:37. DOI: 10.1186/s12938-018-0463-y.

## 1. Create the mesh

This procedure consists in six steps. The input is a T1 weighted MRI and the output is a volumetric mesh with five compartments, i.e., scalp, skull, cerebrospinal fluid (CSF), gray and white matter.

### a. load the MRI

```
mri_orig = ft_read_mri('subject01.nii');
```

Visualize the MRI

```
cfg = [];
ft_sourceplot(cfg,mri_orig);
```

*Figure2: visualization of the MRI*

### b. realign the MRI

In this step we will interactively align the MRI to the CTF space. We will be asked to identify the three CTF landmarks (nasion, NAS; right pre-auricular point, RPA; left pre-auricular point, LPA) in the MRI.

```
cfg = [];
cfg.method = 'interactive';
cfg.coordsys = 'ctf';
mri_realigned = ft_volumerealign(cfg, mri_orig);
```

We can visualize the realigned MRI

```
cfg = [];
ft_sourceplot(cfg, mri_realigned);
```

### c. reslice the MRI

```
cfg = [];
mri_resliced = ft_volumereslice(cfg, mri_realigned);
```

We can visualize the resliced MRI

```
cfg = [];
ft_sourceplot(cfg, mri_resliced);
```

*Figure3: visualization of the replaced MRI*

### d. create surface meshes

For visualization purposes, we produce surface meshes for three compartments: scalp, skull and brain. In order to do that, we first have to segment the MRI into the three compartments.

```
cfg = [];
cfg.output = {'scalp','skull', 'brain'};
mri_segmented_3_compartment = ft_volumesegment(cfg, mri_resliced);
```

Visualize the segmentation

```
seg_i = ft_datatype_segmentation(mri_segmented_3_compartment,'segmentationstyle','indexed');
cfg = [];
cfg.funparameter = 'seg';
cfg.funcolormap = gray(4); % distinct color per tissue
cfg.location = 'center';
cfg.atlas = seg_i;
ft_sourceplot(cfg, seg_i);
```

*Figure4: 3 compartment segmentation output*

Once the segmentation is completed, the three surface meshes can be computed.

```
cfg =[];
cfg.tissue = {'scalp','skull','brain'};
cfg.numvertices = [3000 2000 1000];
mesh_surf = ft_prepare_mesh(cfg,mri_segmented_3_compartment);
```

We can save the mesh obtained

```
save mesh_surf mesh_surf
```

### e. segment the MRI

```
cfg = [];
cfg.output = {'scalp','skull','csf','gray','white'};
cfg.brainsmooth = 2;
cfg.skullsmooth = 2;
cfg.scalpsmooth = 2;
mri_segmented_5_compartment = ft_volumesegment(cfg, mri_resliced);
```

Visualize the segmentation result

```
seg_i = ft_datatype_segmentation(mri_segmented_5_compartment,'segmentationstyle','indexed');
seg_i = ft_datatype_segmentation(mri_segmented_5_compartment,'segmentationstyle','indexed');
cfg = [];
cfg.funparameter = 'seg';
cfg.funcolormap = gray(6); % distinct color per tissue (air is included)
cfg.location = 'center';
cfg.atlas = seg_i; % the segmentation can also be used as atlas
ft_sourceplot(cfg, seg_i);
```

*Figure 8: 5 compartment segmentation output.*

### f. create the mesh

```
cfg = [];
cfg.shift = 0.3;
cfg.method = 'hexahedral';
cfg.resolution = 2; % this is in mm
cfg.tissue = {'scalp', 'skull', 'csf', 'gray','white'};
mesh_fem = ft_prepare_mesh(cfg,mri_segmented_5_compartment);
```

For this tutorial we downsample the mesh to 2mm resolution, in order to reduce the computation time of the following steps.

## EEG and MEG forward solution computation

Once the volumetric mesh has been created, the forward solution can be computed. In the following, steps 2-5 are described for EEG and MEG separately.

Currently, the pipeline for computing the MEG forward problem solution has been tested on Ubuntu systems, where Matlab should be started with the following command:

BLAS_VERSION=/usr/lib/libblas.so LD_PRELOAD=/usr/lib/x86_64-linux-gnu/libstdc++.so.6 ./matlab

## 2(EEG). Create the head-model

```
cfg = [];
cfg.method = 'simbio';
cfg.conductivity = [0.43 0.01 1.79 0.33 14];
cfg.tissuelabel = {'scalp', 'skull', 'csf', 'gray','white'};
headmodel_fem_eeg = ft_prepare_headmodel(cfg, mesh_fem);
```

Visualize the headmodel and the electrodes (it might take time and memory)

```
% scalp: 1, skull: 2, csf: 3, gray: 4, wm: 5
ts = 1;
figure
mesh2 =[];
mesh2.hex = headmodel_fem_eeg.hex(headmodel_fem_eeg.tissue==ts,:); %mesh2.hex(1:size(mesh2.hex),:);
mesh2.pos = headmodel_fem_eeg.pos;
mesh2.tissue = headmodel_fem_eeg.tissue(headmodel_fem_eeg.tissue==ts,:);%mesh.tissue(1:size(mesh2.hex),:);
mesh_ed = mesh2edge(mesh2);
patch('Faces',mesh_ed.poly,...
'Vertices',mesh_ed.pos,...
'FaceAlpha',.5,...
'LineStyle','none',...
'FaceColor',[1 1 1],...
'FaceLighting','gouraud');
xlabel('coronal');
ylabel('sagital');
zlabel('axial')
camlight;
axis on;
ft_plot_sens(elec, 'style', '*g');
```

*Figure9: visualization of headmodel_fem_eeg and electrodes*

## 3(EEG). Create the source-model

In this phase, source locations are selected within the gray matter compartment. During this tutorial we recommend to create a rather coarse grid (cfg.grid.resolution = 5;), in order to be able to compute the forward solution in the time available in this course.

```
cfg = [];
cfg.grid.resolution = 5; %in mm
cfg.vol = headmodel_fem_eeg;
cfg.inwardshift = 1; %shifts dipoles away from surfaces
sourcemodel = ft_prepare_sourcemodel(cfg, headmodel_fem_eeg);
```

We can visualize the sources and the scalp surface mes

```
figure, ft_plot_mesh(sourcemodel.pos(sourcemodel.inside,:))
hold on, ft_plot_mesh(mesh_surf(1),'surfaceonly','yes','vertexcolor','none','facecolor',...
'skin','facealpha',0.5,'edgealpha',0.1)
```

*Figure9: visualization of the source model*

## 4(EEG). Handle the sensors

In case the electrodes are not aligned to the MRI (i.e., CTF space), we can use the interactive function as follows

```
cfg = [];
cfg.method = 'interactive';
cfg.elec = elec;
cfg.headshape = mesh_surf(1);
elec = ft_electroderealign(cfg);
```

*Figure9: visualization of headmodel_fem_eeg and electrodes*

## 5(EEG). Compute the leadfield

Please DO NOT run *ft_prepare_vol_sens* in this tutorial session! It will take too much time and memory. Load “headmodel_fem_eeg_tr”.

```
%% compute the transfer matrix
[headmodel_fem_eeg_tr, elec] = ft_prepare_vol_sens(headmodel_fem_eeg, elec);
%% compute the leadfield
cfg = [];
cfg.grid = sourcemodel;
cfg.vol = headmodel_fem_eeg_tr;
cfg.elec = elec;
cfg.reducerank = 3;
leadfield_fem_eeg = ft_prepare_leadfield(cfg);
```

## 2(MEG). Create the head-model

```
cfg = [];
cfg.method = 'duneuro';
cfg.conductivity = [0.43 0.01 1.79 0.33 0.14]; % check that the order is the same as the one i the mesh_fem
headmodel_fem_meg = ft_prepare_headmodel(cfg, mesh_fem);
```

## 3(MEG). Create the source-model

If the source-model was already created at the step 3(EEG), it can be simply loaded for this step.

```
cfg = [];
cfg.grid.resolution = 5; %in mm
cfg.vol = headmodel_fem_meg;
cfg.inwardshift = 1; %shifts dipoles away from surfaces
sourcemodel = ft_prepare_sourcemodel(cfg, headmodel_fem_meg);
```

We can visualize the sources and the scalp surface mes

```
figure, ft_plot_mesh(sourcemodel.pos(sourcemodel.inside,:))
hold on, ft_plot_mesh(mesh_surf(1),'surfaceonly','yes','vertexcolor','none','facecolor',...
'skin','facealpha',0.5,'edgealpha',0.1)
```

## 4(MEG). Handle the sensors

As already mentioned, the MRI was realigned to the CTF space, therefore there is no need to realign the sensors. We load them from the data.

```
hdr = ft_read_header('subject01.ds','headerformat', 'ctf_ds');
grad_cm = hdr.grad;
grad = ft_convert_units(grad_cm,'mm');
```

We can visualize both EEG and MEG sensors, together with the scalp surface mesh

```
figure
hold on
ft_plot_mesh(mesh_fem,'surfaceonly','yes','vertexcolor','none','edgecolor','none','facecolor',[0.5 0.5 0.5],'facealpha',0.1, 'edgealpha', 0.1);
camlight
axis on
ft_plot_sens(grad,'style', 'sr', 'coil', 'yes');
ft_plot_sens(elec);
```

## 5(MEG). Compute the leadfield

Please DO NOT run *ft_prepare_vol_sens* in this tutorial session! It will take too much time and memory. Load “headmodel_fem_eeg_tr”.

```
%% compute the transfer matrix
[headmodel_fem_meg_tr, grad] = ft_prepare_vol_sens(headmodel_fem_meg, grad, 'channel', MEG_avg.label);
load headmodel_fem_meg_tr
meg_transfer = headmodel_fem_meg_tr.meg_transfer;
headmodel_fem_meg_tr =headmodel_fem_meg;
headmodel_fem_meg_tr.meg_transfer = meg_transfer;
%% compute the leadfield
cfg = [];
cfg.grid = sourcemodel;
cfg.headmodel = headmodel_fem_meg_tr;
cfg.grad = grad;
cfg.reducerank = 2;
leadfield_fem_meg = ft_prepare_leadfield(cfg);
```

## Exercises

#### Exercise 1

Realign the electrodes in the file *elec_shifted.mat* to the head-model you created.

#### Exercise 2

[NOT NOW!] Compute a finer sourcemodel, e.g., 2 mm resolution and compute the respective EEG and MEG forward solutions.

#### Exercise 3

Compute the EEG and MEG forward solution using the Boundary Element Method (BEM), e.g., following this tutorial.

## Summary and Comments

This tutorial was about the computation of leadfields that could be feed into the inverse problem which will be explain i Inverse problem.

This tutorial was last tested on 14-06-2018 by Simon Homölle on Mac, Matlab 2015b.